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Reciprocal regulation of carbon monoxide metabolism and the circadian clock

Klemz, Roman ; Reischl, Silke ; Wallach, Thomas ; Witte, Nicole ; Jürchott, Karsten ; Klemz, Sabrina ; Lang, Veronika ; Lorenzen, Stephan ; Knauer, Miriam ; Heidenreich, Steffi ; Xu, Min ; Ripperger, Jürgen A. ; Schupp, Michael ; Stanewsky, Ralf ; Kramer, Achim

In: Nature Structural & Molecular Biology, 2017, vol. 24, no. 1, p. 15-22

Circadian clocks are cell-autonomous oscillators regulating daily rhythms in a wide range of physiological, metabolic and behavioral processes. Feedback of metabolic signals, such as redox state, NAD+/NADH and AMP/ADP ratios, or heme, modulate circadian rhythms and thereby optimize energy utilization across the 24-h cycle. We show that rhythmic heme degradation, which generates the signaling...