In: iScience, 2020, vol. 23, no. 3, p. 100932
Pathogenic bacteria secrete virulence factors that interact with the human host to establish infections. The human immune system evolved multiple mechanisms to fight bacterial invaders, including immune proteases that were demonstrated to contribute crucially to antibacterial defense. Here we show that granzyme B degrades multiple secreted virulence mediators from Listeria monocytogenes,...
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In: The Journal of Immunology, 2020, vol. 204, no. 7, p. 1798–1809
Plasmodium spp., the causative agent of malaria, have a complex life cycle. The exponential growth of the parasites during the blood stage is responsible for almost all malaria-associated morbidity and mortality. Therefore, tight immune control of the intraerythrocytic replication of the parasite is essential to prevent clinical malaria. Despite evidence that the particular lymphocyte subset ...
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In: Frontiers in Immunology, 2020, vol. 11, p. -
Malaria infection caused by the Plasmodium species is a complex disease in which a fine balance between host and parasite factors determine the outcome of the disease. While in some individuals, the infection will trigger only a mild and uncomplicated disease, other individuals will develop severe complications and eventually die. Extracellular vesicles (EVs) secreted by infected red blood...
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In: Pathogens, 2020, vol. 9, no. 1, p. 21
Microglia are the chief immune cells of the brain and have been reported to be activated in severe malaria. Their activation may drive towards neuroinflammation in cerebral malaria. Malaria-infected red blood cell derived-extracellular vesicles (MiREVs) are produced during the blood stage of malaria infection. They mediate intercellular communication and immune regulation, among other...
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In: JoVE (Journal of Visualized Experiments), 2018, no. 132, p. e57067
Malaria is a life-threatening disease caused by Plasmodium parasites, with P. falciparum being the most prevalent on the African continent and responsible for most malaria-related deaths globally. Several factors including parasite sequestration in tissues, vascular dysfunction, and inflammatory responses influence the evolution of the disease in malaria-infected people. P. falciparum-infected...
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In: The Journal of Membrane Biology, 2006, vol. 212, no. 1, p. 29-39
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In: Histochemistry and Cell Biology, 2005, vol. 123, no. 2, p. 169-178
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In: Nanomedicine: Nanotechnology, Biology and Medicine, 2018, vol. 14, no. 2, p. 601–607
Bone infections are difficult to treat and can lead to severe tissue destruction. Acute bone infections are usually caused by Staphylococcus aureus. Osteoclasts, which belong to the monocyte/macrophage lineage, are the key cells in bone infections. They are not well equipped for killing bacteria and may serve as a reservoir for bacterial pathogens. Silver has been known for centuries for its...
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In: Scientific Reports, 2018, vol. 8, no. 1, p. 884
The parasite Plasmodium falciparum causes the most severe form of malaria. Cell communication between parasites is an important mechanism to control population density and differentiation. The infected red blood cells (iRBCs) release small extracellular vesicles (EVs) that transfer cargoes between cells. The EVs synchronize the differentiation of the asexual parasites into gametocytes to initiate...
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In: Cell Death & Differentiation, 2017, vol. 24, no. 4, p. 747–758
We have found that granzyme B (GB)-induced apoptosis also requires reactive oxygen species resulting from the alteration of mitochondrial complex I. How GB, which does not possess a mitochondrial targeting sequence, enter this organelle is unknown. We show that GB enters the mitochondria independently of the translocase of the outer mitochondrial membrane complex, but requires instead Sam50,...
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