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    2 risultati 1
    Université de Fribourg

    Magi1, a new potential tumor suppressor gene in estrogen receptor positive breast cancer

    Alday-Parejo, Begoña ; Richard, François ; Wörthmüller, Janine ; Rau, Tilman ; Galván, José A. ; Desmedt, Christine ; Santamaria-Martinez, Albert ; Rüegg, Curzio

    In: Cancers, 2020, vol. 12, no. 1, p. 223

    Membrane-associated guanylate kinase (MAGUK) with inverted domain structure-1 (MAGI1) is an intracellular adaptor protein that stabilizes epithelial junctions consistent with a tumor suppressive function in several cancers of epithelial origin. Here we report, based on experimental results and human breast cancer (BC) patients’ gene expression data, that MAGI1 is highly expressed and acts...

    Université de Fribourg

    Modulation of calretinin expression in human mesothelioma cells reveals the implication of the fak and wnt signaling pathways in conferring chemoresistance towards cisplatin

    Wörthmüller, Janine ; Salicio, Valérie ; Oberson, Anne ; Blum, Walter ; Schwaller, Beat

    In: International Journal of Molecular Sciences, 2019, vol. 20, no. 21, p. 5391

    Malignant mesothelioma (MM) is an aggressive asbestos-linked neoplasm, characterized by dysregulation of signaling pathways. Due to intrinsic or acquired chemoresistance, MM treatment options remain limited. Calretinin is a Ca2+-binding protein expressed during MM tumorigenesis that activates the FAK signaling pathway, promoting invasion and epithelial-to-mesenchymal transition. Constitutive...

    2 risultati 1