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Role of mutation of the circadian clock gene Per2 in cardiovascular circadian rhythms

Vukolic, Ana ; Antic, Vladan ; Vliet, Bruce N. Van ; Yang, Zhihong ; Albrecht, Urs ; Montani, Jean-Pierre

In: American Journal of Physiology Regulatory, Integrative and Comparative Physiolology, 2010, p. -

Alterations in the circadian blood pressure pattern are frequently observed in hypertension and lead to increased cardiovascular morbidity. However, there are no studies that have investigated a possible implication of the Period2 gene, a key component of the molecular circadian clock, on the circadian rhythms of blood pressure and heart rate. To address this question, we monitored blood...