In: Amino Acids, 2015, vol. 47, no. 4, p. 693-705
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In: Pflügers Archiv - European Journal of Physiology, 2009, vol. 458, no. 1, p. 53-60
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In: Pflügers Archiv, 2005, vol. 451, no. 2, p. 338-348
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In: Pflügers Archiv, 2004, vol. 447, no. 5, p. 532-542
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In: Journal of the American Heart Association, 2018, vol. 7, no. 5, p. e008025
Background Uninephrectomy (UNX) is performed for various reasons, including kidney cancer or donation. Kidneys being the main site of L‐arginine production in the body, we tested whether UNX mediated kidney mass reduction impacts L‐arginine metabolism and thereby nitric oxide production and blood pressure regulation in mice. Methods and Results In a first series of experiments, we observed...
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In: Nephrology Dialysis Transplantation, 2007, vol. 22, no. 9, p. 2449-2451
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In: Human Molecular Genetics, 2013, vol. 22, no. 16, p. 3218-3226
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In: European Heart Journal, 2013, vol. 34, no. 45, p. 3515-3524
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In: Frontiers in Physiology, 2016, vol. 7, p. -
Obesity is associated with development and progression of chronic kidney disease (CKD). Recent evidence demonstrates that enhanced levels of the L- arginine:ureahydrolase, including the two isoenzymes arginase-I (Arg-I) and arginase- II (Arg-II) in vascular endothelial cells promote uncoupling of endothelial nitric oxide synthase (eNOS), leading to increased superoxide radical anion and...
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In: American Journal of Physiology: Renal Physiology, 2008, vol. 294, no. 6, p. F1373-F1380
ROMK-deficient (Romk–/–) mice exhibit polyuria, natriuresis, and kaliuresis similar to individuals with type II Bartter's form of hyperprostaglandin E syndrome (HPS; antenatal Bartter's syndrome). In the present study, we utilized both metabolic and clearance studies to define the contributions of specific distal nephron segments to the renal salt wasting in these mice. The...
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