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SLC1 and SLC4 encode partially redundant acyl-Coenzyme A 1-acylglycerol-3-phosphate O-acyltransferases of budding yeast

Benghezal, Mohammed ; Roubaty, Carole ; Veepuri, Vijayanath ; Knudsen, Jens ; Conzelmann, Andreas

In: Journal of Biological Chemistry, 2007, p. jbc.M702719200

Phosphatidic acid (PA) is the intermediate, from which all glycerophospholipids are synthesized. In yeast it is generated from lyso-phosphatidic acid, which is acylated by Slc1p, a sn-2-specific, acyl-Coenzyme A-dependent 1-acylglycerol-3-phosphate O-acyltransferase. Deletion of SLC1 is not lethal and does not eliminate all microsomal 1-acylglycerol-3-phosphate O-acyltransferase activity...