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Improved dynamic response assessment for intra-articular injected iron oxide nanoparticles

Crowe, L. A. ; Tobalem, F. ; Gramoun, A. ; Delattre, B. M. A. ; Grosdemange, K. ; Salaklang, Jatuporn ; Redjem, A. ; Petri-Fink, Alke ; Hofmann, Heinrich ; Vallée, J.-P.

In: Magnetic Resonance in Medicine, 2012, vol. 68, no. 5, p. 1544–1552

The emerging importance of nanoparticle technology, including iron oxide nanoparticles for monitoring development, progression, and treatment of inflammatory diseases such as arthritis, drives development of imaging techniques. Studies require an imaging protocol that is sensitive and quantifiable for the detection of iron oxide over a wide range of concentrations. Conventional signal loss...