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Tsr4 and Nap1, two novel members of the ribosomal protein chaperOME

Rössler, Ingrid ; Embacher, Julia ; Pillet, Benjamin ; Murat, Guillaume ; Liesinger, Laura ; Hafner, Jutta ; Unterluggauer, Julia Judith ; Birner-Gruenberger, Ruth ; Kressler, Dieter ; Pertschy, Brigitte

In: Nucleic Acids Research, 2019, p. gkz317

Dedicated chaperones protect newly synthesized ribosomal proteins (r-proteins) from aggregation and accompany them on their way to assembly into nascent ribosomes. Currently, only nine of the ∼80 eukaryotic r-proteins are known to be guarded by such chaperones. In search of new dedicated r-protein chaperones, we performed a tandem-affinity purification based screen and looked for factors...