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Protein glutaminylation is a yeast-specific posttranslational modification of elongation factor 1A

Jank, Thomas ; Belyi, Yury ; Wirth, Christophe ; Rospert, Sabine ; Hu, Zehan ; Dengjel, Jörn ; Tzivelekidis, Tina ; Andersen, Gregers Rom ; Hunte, Carola ; Schlosser, Andreas ; Aktories, Klaus

In: Journal of Biological Chemistry, 2017, vol. 292, no. 39, p. 16014–16023

Ribosomal translation factors are fundamental for protein synthesis and highly conserved in all kingdoms of life. The essential eukaryotic elongation factor 1A (eEF1A) delivers aminoacyl tRNAs to the A-site of the translating 80S ribosome. Several studies have revealed that eEF1A is posttranslationally modified. Using MS analysis, site-directed mutagenesis, and X-ray structural data analysis of...