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    Université de Fribourg

    Increased resistance to carbapenems in proteus mirabilis mediated by amplification of the bla vim-1 -carrying and is 26 -associated class 1 integron

    Bontron, Séverine ; Poirel, Laurent ; Kieffer, Nicolas ; Savov, Encho ; Trifonova, Angelina ; Todorova, Iva ; Kueffer, Gwendoline ; Nordmann, Patrice

    In: Microbial Drug Resistance, 2019, vol. 25, no. 5, p. 663–667

    The aim of the study was to decipher the mechanisms and associated genetic determinants responsible for increased carbapenem resistance among Proteus mirabilis clinical isolates.Methods: The entire genetic structure surrounding the β- lactam resistance genes was characterized by PCR, gene walking, and DNA sequencing.Results: A series of clinical P. mirabilis isolates were consecutively ...

    Université de Fribourg

    Outbreak caused by NDM-1- and RmtB-producing Escherichia coli in Bulgaria

    Poirel, Laurent ; Savov, Encho ; Nazli, Arzu ; Trifonova, Angelina ; Todorova, Iva ; Gergova, Ivanka ; Nordmann, Patrice

    In: Antimicrobial Agents and Chemotherapy, 2014, vol. 58, no. 4, p. 2472–2474

    Twelve consecutive carbapenem-resistant Escherichia coli isolates were recovered from patients (infection or colonization) hospitalized between March and September 2012 in different units at a hospital in Bulgaria. They all produced the carbapenemase NDM-1 and the extended-spectrum-β-lactamase CTX-M-15, together with the 16S rRNA methylase RmtB, conferring high-level resistance to all...

    2 results 1