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Myocardial infarction stabilization by cell-based expression of controlled Vascular Endothelial Growth Factor levels

Melly, Ludovic ; Cerino, Giulia ; Frobert, Aurélien ; Cook, Stéphane ; Giraud, Marie-Noëlle ; Carrel, Thierry ; Tevaearai Stahel, Hendrik T. ; Eckstein, Friedrich ; Rondelet, Benoît ; Marsano, Anna ; Banfi, Andrea

In: Journal of Cellular and Molecular Medicine, 2018, p. -

Vascular Endothelial Growth Factor (VEGF) can induce normal or aberrant angiogenesis depending on the amount secreted in the microenvironment around each cell. Towards a possible clinical translation, we developed a Fluorescence Activated Cell Sorting (FACS)‐based technique to rapidly purify transduced progenitors that homogeneously express a desired specific VEGF level from heterogeneous...