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    2 Ergebnisse 1
    Université de Fribourg

    Effects of the poly(ADP-ribose) polymerase inhibitor olaparib in cerulein-induced pancreatitis

    Ahmad, Akbar ; Haas De Mello, Aline ; Szczesny, Bartosz ; Törö, Gábor ; Marcatti, Michela ; Druzhyna, Nadiya ; Liaudet, Lucas ; Tarantini, Stefano ; Salomao, Reinaldo ; Garcia Soriano, Francisco ; Szabo, Csaba

    In: Shock, 2020, vol. 53, no. 5, p. 653–665

    Objective: Activation of the constitutive nuclear and mitochondrial enzyme poly (ADP- ribose) polymerase (PARP) has been implicated in the pathogenesis of cell dysfunction, inflammation, and organ failure in various forms of critical illness. The objective of our study was to evaluate the efficacy and safety of the clinically approved PARP inhibitor olaparib in an experimental model of...

    Université de Fribourg

    Nicotinamide mononucleotide (NMN) supplementation promotes anti-aging miRNA expression profile in the aorta of aged mice, predicting epigenetic rejuvenation and anti-atherogenic effects

    Kiss, Tamas ; Giles, Cory B. ; Tarantini, Stefano ; Yabluchanskiy, Andriy ; Balasubramanian, Priya ; Gautam, Tripti ; Csipo, Tamas ; Nyúl-Tóth, Ádám ; Lipecz, Agnes ; Szabo, Csaba ; Farkas, Eszter ; Wren, Jonathan D. ; Csiszar, Anna ; Ungvari, Zoltan

    In: Published version; http://dx.doi.org/10.1007/s11357-019-00095-x, 2019, p. -

    Understanding molecular mechanisms involved in vascular aging is essential to develop novel interventional strategies for treatment and prevention of age-related vascular pathologies. Recent studies provide critical evidence that vascular aging is characterized by NAD+ depletion. Importantly, in aged mice, restoration of cellular NAD+ levels by treatment with the NAD+ booster nicotinamide...

    2 Ergebnisse 1