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Surprising lack of liposome-induced complement activation by artificial 1,3-diamidophospholipids in vitro

Bugna, Simon ; Buscema, Marzia ; Matviykiv, Sofiya ; Urbanics, Rudolf ; Weinberger, Andreas ; Meszaros, Tamas ; Szebeni, Janos ; Zumbuehl, Andreas ; Saxer, Till ; Müller, Bert

In: Nanomedicine: Nanotechnology, Biology and Medicine, 2016, vol. 12, no. 3, p. 845–849

Cardio-vascular diseases are the main cause of death, emphasizing the need to improve patient treatment and survival. One therapeutic approach is a liposome-based drug carrier system specifically targeting constricted arteries. The recently discovered mechano-sensitive liposomes use hemodynamic shear-stress differences between healthy and constricted blood vessels as trigger for drug release....