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Silver coordination polymers for prevention of implant infection: thiol interaction, impact on respiratory chain enzymes, and hydroxyl radical induction

Gordon, Oliver ; Slenters, Tünde Vig ; Brunetto, Priscilla S. ; Villaruz, Amer E. ; Sturdevant, Daniel E. ; Otto, Michael ; Landmann, Regine ; Fromm, Katharina M.

In: Antimicrobial Agents and Chemotherapy, 2010, vol. 54, no. 10, p. 4208-4218

Prosthetic joint replacements are used increasingly to alleviate pain and improve mobility of the progressively older and more obese population. Implant infection occurs in about 5% of patients and entails significant morbidity and high social costs. It is most often caused by staphylococci, which are introduced perioperatively. They are a source of prolonged seeding and difficult to treat...