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Crystal Structure of DIM-1, an Acquired Subclass B1 Metallo-β-Lactamase from Pseudomonas stutzeri

Booth, Michael P. S. ; Kosmopoulou, Magda ; Poirel, Laurent ; Nordmann, Patrice ; Spencer, James

In: PLoS ONE, 2015, vol. 10, no. 10, p. e0140059

Metallo-β-lactamases (MBLs) hydrolyze almost all classes of β-lactam antibiotic, including carbapenems—currently first choice drugs for opportunistic infections by Gram-negative bacterial pathogens. MBL inhibitor development is complicated by the diversity within this group of enzymes, and by the appearance of new enzymes that continue to be identified both as chromosomal genes and on mobile...