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Nicotinic Cholinergic Signaling in Adipose Tissue and Pancreatic Islets Biology: Revisited Function and Therapeutic Perspectives

Somm, Emmanuel

In: Archivum Immunologiae et Therapiae Experimentalis, 2014, vol. 62, no. 2, p. 87-101

Β-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue

Somm, Emmanuel ; Henry, Hugues ; Bruce, Stephen J. ; Aeby, Sébastien ; Rosikiewicz, Marta ; Sykiotis, Gerasimos P. ; Asrih, Mohammed ; Jornayvaz, François R. ; Denechaud, Pierre Damien ; Albrecht, Urs ; Mohammadi, Moosa ; Dwyer, Andrew ; Jr., James S. Acierno ; Schoonjans, Kristina ; Fajas, Lluis ; Greub, Gilbert ; Pitteloud, Nelly

In: JCI Insight, 2017, vol. 2, no. 8, p. -

β-Klotho (encoded by Klb) is the obligate coreceptor mediating FGF21 and FGF15/19 signaling. Klb–/– mice are refractory to beneficial action of pharmacological FGF21 treatment including stimulation of glucose utilization and thermogenesis. Here, we investigated the energy homeostasis in Klb–/– mice on high-fat diet in order to better understand the consequences of abrogating both...