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Amide proton transfer weighted imaging shows differences in multiple sclerosis lesions and white matter hyperintensities of presumed vascular origin

Sartoretti, Elisabeth ; Sartoretti, Thomas ; Wyss, Michael ; Becker, Anton S. ; Schwenk, Árpád ; Smoorenburg, Luuk van ; Najafi, Arash ; Binkert, Christoph ; Thoeny, Harriet C. ; Zhou, Jinyuan ; Jiang, Shanshan ; Graf, Nicole ; Czell, David ; Sartoretti-Schefer, Sabine ; Reischauer, Carolin

In: Frontiers in Neurology, 2019, vol. 10, p. -

Objectives: To assess the ability of 3D amide proton transfer weighted (APTw) imaging based on magnetization transfer analysis to discriminate between multiple sclerosis lesions (MSL) and white matter hyperintensities of presumed vascular origin (WMH) and to compare APTw signal intensity of healthy white matter (healthy WM) with APTw signal intensity of MSL and WHM.Materials and Methods: A...