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Chemokine receptor patterns in lymphocytes mirror metastatic spreading in melanoma

Jacquelot, Nicolas ; Enot, David P. ; Flament, Caroline ; Vimond, Nadège ; Blattner, Carolin ; Pitt, Jonathan M. ; Yamazaki, Takahiro ; Roberti, María Paula ; Daillère, Romain ; Vétizou, Marie ; Poirier-Colame, Vichnou ; Semeraro, Michaëla ; Caignard, Anne ; Slingluff Jr., Craig L. ; Sallusto, Federica ; Rusakiewicz, Sylvie ; Weide, Benjamin ; Marabelle, Aurélien ; Kohrt, Holbrook ; Dalle, Stéphane ; Cavalcanti, Andréa ; Kroemer, Guido ; Di Giacomo, Anna Maria ; Maio, Michele ; Wong, Phillip ; Yuan, Jianda ; Wolchok, Jedd ; Umansky, Viktor ; Eggermont, Alexander ; Zitvogel, Laurence

In: The journal of clinical investigation, 2016, vol. 126, no. 3, p. 921-937

Melanoma prognosis is dictated by tumor-infiltrating lymphocytes, the migratory and functional behavior of which is guided by chemokine or cytokine gradients. Here, we retrospectively analyzed the expression patterns of 9 homing receptors (CCR/CXCR) in naive and memory CD4+ and CD8+ T lymphocytes in 57 patients with metastatic melanoma (MMel) with various sites of metastases to evaluate...