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Phosphoproteomic profiling reveals a defined genetic program for osteoblastic lineage commitment of human bone marrow–derived stromal stem cells

Barrio-Hernandez, Inigo ; Jafari, Abbas ; Rigbolt, Kristoffer T.G. ; Hallenborg, Philip ; Sanchez-Quiles, Virginia ; Skovrind, Ida ; Akimov, Vyacheslav ; Kratchmarova, Irina ; Dengjel, Jörn ; Kassem, Moustapha ; Blagoev, Blagoy

In: Genome Research, 2020, vol. 30, no. 1, p. 127-137

Bone marrow–derived mesenchymal stem cells (MSCs) differentiate into osteoblasts upon stimulation by signals present in their niche. Because the global signaling cascades involved in the early phases of MSCs osteoblast (OB) differentiation are not well-defined, we used quantitative mass spectrometry to delineate changes in human MSCs proteome and phosphoproteome during the first 24 h of...