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    Université de Fribourg

    Protein complexes and neighborhoods driving autophagy

    Siva Sankar, Devanarayanan ; Dengjel, Jörn

    In: Autophagy, 2020, vol. 0, no. 0, p. 1–17

    Autophagy summarizes evolutionarily conserved, intracellular degradation processes targeting cytoplasmic material for lysosomal degradation. These encompass constitutive processes as well as stress responses, which are often found dysregulated in diseases. Autophagy pathways help in the clearance of damaged organelles, protein aggregates and macromolecules, mediating their recycling and ...