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Co-translational capturing of nascent ribosomal proteins by their dedicated chaperones

Pausch, Patrick ; Singh, Ujjwala ; Ahmed, Yasar Luqman ; Pillet, Benjamin ; Murat, Guillaume ; Altegoer, Florian ; Stier, Gunter ; Thoms, Matthias ; Hurt, Ed ; Sinning, Irmgard ; Bange, Gert ; Kressler, Dieter

In: Nature Communications, 2015, vol. 6, p. 7494

Exponentially growing yeast cells produce every minute >160,000 ribosomal proteins. Owing to their difficult physicochemical properties, the synthesis of assembly-competent ribosomal proteins represents a major challenge. Recent evidence highlights that dedicated chaperone proteins recognize the N-terminal regions of ribosomal proteins and promote their soluble expression and delivery to the...

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Mak5 and Ebp2 act together on early Pre-60S particles and their reduced functionality bypasses the requirement for the essential Pre-60S factor Nsa1

Pratte, Dagmar ; Singh, Ujjwala ; Murat, Guillaume ; Kressler, Dieter

In: PLoS ONE, 2013, vol. 8, no. 12, p. e82741

Ribosomes are the molecular machines that translate mRNAs into proteins. The synthesis of ribosomes is therefore a fundamental cellular process and consists in the ordered assembly of 79 ribosomal proteins (r-proteins) and four ribosomal RNAs (rRNAs) into a small 40S and a large 60S ribosomal subunit that form the translating 80S ribosomes. Most of our knowledge concerning this dynamic multi-step...

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