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MP2RAGE provides new clinically-compatible correlates of mild cognitive deficits in relapsing-remitting multiple sclerosis

Simioni, Samanta ; Amarù, Fabio ; Bonnier, Guillaume ; Kober, Tobias ; Rotzinger, David ; Du Pasquier, Renaud ; Schluep, Myriam ; Meuli, Reto ; Sbarbati, Andrea ; Thiran, Jean-Philippe ; Krueger, Gunnar ; Granziera, Cristina

In: Journal of Neurology, 2014, vol. 261, no. 8, p. 1606-1613

Rivastigmine for HIV-associated neurocognitive disorders A randomized crossover pilot study

Simioni, Samanta ; Cavassini, Matthias ; Annoni, Jean-Marie ; Iglesias, Mélanie Métral, Katia ; Abraham, Aline Rimbault ; Jilek, Samantha ; Calmy, Alexandra ; Müller, Hubertus ; Fayet-Mello, Aurélie ; Giacobini, Ezio ; Hirschel, Bernard ; Pasquier, Renaud A. Du

In: Neurology, 2013, vol. 80, no. 6, p. 553–560

Objective: To assess the efficacy and safety of rivastigmine for the treatment of HIV-associated neurocognitive disorders (HAND) in a cohort of long-lasting aviremic HIV+ patients.Methods: Seventeen aviremic HIV+ patients with HAND were enrolled in a randomized, double-blind, placebo-controlled, crossover study to receive either oral rivastigmine (up to 12 mg/day for 20 weeks) followed by placebo...

Principal components of functional connectivity: a new approach to study dynamic brain connectivity during rest

Leonardi, Nora ; Richiardi, Jonas ; Gschwind, Markus ; Simioni, Samanta ; Annoni, Jean-Marie ; Schluep, Myriam ; Vuilleumier, Patrik ; Ville, Dimitri Van De

In: NeuroImage, 2013, p. -

Functional connectivity (FC) as measured by correlation between fMRI BOLD time courses of distinct brain regions has revealed meaningful organization of spontaneous fluctuations in the resting brain. However, an increasing amount of evidence points to non-stationarity of FC; i.e., FC dynamically changes over time reflecting additional and rich information about brain organization, but...

Multiple sclerosis decreases explicit counterfactual processing and risk taking in decision making

Simioni, Samanta ; Schluep, Myriam ; Bault, Nadège ; Coricelli, Giorgio ; Kleeberg, Joerg ; Pasquier, Renaud A. Du ; Gschwind, Markus ; Vuilleumier, Patrik ; Annoni, Jean-Marie

In: PLoS ONE, 2012, vol. 7, no. 12, p. e50718

Deficits in decision making (DM) are commonly associated with prefrontal cortical damage, but may occur with multiple sclerosis (MS). There are no data concerning the impact of MS on tasks evaluating DM under explicit risk, where different emotional and cognitive components can be distinguished.Methods: We assessed 72 relapsing-remitting MS (RRMS) patients with mild to moderate disease and 38...