Affiner les résultats

Seipin accumulates and traps diacylglycerols and triglycerides in its ring-like structure

Zoni, Valeria ; Khaddaj, Rasha ; Lukmantara, Ivan ; Shinoda, Wataru ; Hongyuan, Yang ; Schneiter, Roger ; Vanni, Stefano

In: Proceedings of the National Academy of Sciences, 2021, vol. 118, no. 10, p. e2017205118

Lipid droplets (LDs) are intracellular organelles responsible for lipid storage, and they emerge from the endoplasmic reticulum (ER) upon the accumulation of neutral lipids, mostly triglycerides (TG), between the two leaflets of the ER membrane. LD biogenesis takes place at ER sites that are marked by the protein seipin, which subsequently recruits additional proteins to catalyze LD formation....