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Absence of the calcium-binding protein calretinin, not of calbindin D-28k, causes a permanent impairment of murine adult hippocampal neurogenesis

Todkar, Kiran ; Scotti, Alessandra L. ; Schwaller, Beat

In: Frontiers In Molecular Neuroscience, 2012, vol. 5, p. 56

Calretinin (CR) and calbindin D-28k (CB) are cytosolic EF-hand Ca²⁺-binding proteins and function as Ca²⁺ buffers affecting the spatiotemporal aspects of Ca²⁺ transients and possibly also as Ca²⁺ sensors modulating signaling cascades. In the adult hippocampal circuitry, CR and CB are expressed in specific principal neurons and subsets of interneurons. In addition, CR is transiently...