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Médiathèque Valais

Les sentences latines de la Maison Supersaxo, à Sion

Schneider, André

In: Vallesia : bulletin annuel de la Bibliothèque et des Archives cantonales du Valais, des Musées de Valère et de la Majorie = Jahrbuch der Walliser Kantonsbibliothek, des Staatsarchivs und der Museen von Valeria und Majoria, 1972, p. 241-247

Université de Fribourg

The direct route: a simplified pathway for protein import into the mitochondrion of trypanosomes

Schneider, André ; Bursać, Dejan ; Lithgow, Trevor

In: Trends in Cell Biology, 2008, vol. 18, no. 1, p. 12-18

Trypanosoma brucei is a unicellular eukaryote that causes the deadly human African trypanosomiasis (‘sleeping sickness’) in humans. The parasite has a complicated lifestyle, it developmentally changes aspects of its mitochondrial function as it alternates from forms in the tsetse fly to forms adapted for life in the human bloodstream. The single mitochondrion found in each trypanosome has to...

Université de Fribourg

Conserved motifs reveal details of ancestry and structure in the small tim chaperones of the mitochondrial intermembrane space

Gentle, Ian E. ; Perry, Andrew J. ; Alcock, Felicity H. ; Likic, Vladimir A. ; Dolezal, Pavel ; Ng, Ee Ting ; Purcell, Anthony W. ; McConnville, Malcolm ; Naderer, Thomas ; Chanez, Anne-Laure ; Charrière, Fabien ; Aschinger, Caroline ; Schneider, André ; Tokatlidis, Kostas ; Lithgow, Trevor

In: Molecular Biology and Evolution, 2007, vol. 24, no. 5, p. 1149-1160

The mitochondrial inner and outer membranes are composed of a variety of integral membrane proteins, assembled into the membranes posttranslationally. The small translocase of the inner mitochondrial membranes (TIMs) are a group of ∼10 kDa proteins that function as chaperones to ferry the imported proteins across the mitochondrial intermembrane space to the outer and inner membranes. In yeast,...

Université de Fribourg

Pentatricopeptide repeat proteins in Trypanosoma brucei function in mitochondrial ribosomes

Pusnik, Mascha ; Small, Ian ; Read, Laurie K. ; Fabbro, Thomas ; Schneider, André

In: Molecular and Cellular Biology, 2007, vol. 27, no. 19, p. 6876-6888

The pentatricopeptide repeat (PPR), a degenerate 35-amino-acid motif, defines a novel eukaryotic protein family. Plants have 400 to 500 distinct PPR proteins, whereas other eukaryotes generally have fewer than 5. The few PPR proteins that have been studied have roles in organellar gene expression, probably via direct interaction with RNA. Here we show that the parasitic protozoan Trypanosoma...

Université de Fribourg

Bax function in the absence of mitochondria in the primitive protozoan Giardia lamblia

Hehl, Adrian B. ; Regos, Attila ; Schraner, Elisabeth ; Schneider, André

In: PLoS ONE, 2007, vol. 2, no. 5, p. e488

Bax-induced permeabilization of the mitochondrial outer membrane and release of cytochrome c are key events in apoptosis. Although Bax can compromise mitochondria in primitive unicellular organisms that lack a classical apoptotic machinery, it is still unclear if Bax alone is sufficient for this, or whether additional mitochondrial components are required. The protozoan parasite Giardia lamblia...