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Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception

Bicker, Frank ; Vasic, Verica ; Horta, Guilherme ; Ortega, Felipe ; Nolte, Hendrik ; Kavyanifar, Atria ; Keller, Stefanie ; Stankovic, Nevenka Dudvarski ; Harter, Patrick N. ; Benedito, Rui ; Lutz, Beat ; Baüerle, Tobias ; Hartwig, Jens ; Baumgart, Jan ; Krüger, Marcus ; Radyushkin, Konstantin ; Alberi, Lavinia ; Berninger, Benedikt ; Schmidt, Mirko H.H.

In: Nature Communications, 2017, vol. 8, p. ncomms15922

Adult neural stem cells reside in a specialized niche in the subventricular zone (SVZ). Throughout life they give rise to adult-born neurons in the olfactory bulb (OB), thus contributing to neural plasticity and pattern discrimination. Here, we show that the neurovascular protein EGFL7 is secreted by endothelial cells and neural stem cells (NSCs) of the SVZ to shape the vascular stem-cell...