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Cell cycle constraints and environmental control of local DNA hypomethylation in α-proteobacteria

Ardissone, Silvia ; Redder, Peter ; Russo, Giancarlo ; Frandi, Antonio ; Fumeaux, Coralie ; Patrignani, Andrea ; Schlapbach, Ralph ; Falquet, Laurent ; Viollier, Patrick H.

In: PLOS Genetics, 2016, vol. 12, no. 12, p. e1006499

Heritable DNA methylation imprints are ubiquitous and underlie genetic variability from bacteria to humans. In microbial genomes, DNA methylation has been implicated in gene transcription, DNA replication and repair, nucleoid segregation, transposition and virulence of pathogenic strains. Despite the importance of local (hypo)methylation at specific loci, how and when these patterns are...

Mining co-regulated gene profiles for the detection of functional associations in gene expression data

Gyenesei, Attila ; Wagner, Ulrich ; Barkow-Oesterreicher, Simon ; Stolte, Etzard ; Schlapbach, Ralph

In: Bioinformatics, 2007, vol. 23, no. 15, p. 1927-1935

PhyloDetect: a likelihood-based strategy for detecting microorganisms with diagnostic microarrays

Rehrauer, Hubert ; Schönmann, Susan ; Eberl, Leo ; Schlapbach, Ralph

In: Bioinformatics, 2008, vol. 24, no. 16, p. i83-i89

Preferred analysis methods for single genomic regions in RNA sequencing revealed by processing the shape of coverage

Okoniewski, Michał J. ; Leśniewska, Anna ; Szabelska, Alicja ; Zyprych-Walczak, Joanna ; Ryan, Martin ; Wachtel, Marco ; Morzy, Tadeusz ; Schäfer, Beat ; Schlapbach, Ralph

In: Nucleic Acids Research, 2012, vol. 40, no. 9, p. e63-e63

New insights into the performance of human whole-exome capture platforms

Meienberg, Janine ; Zerjavic, Katja ; Keller, Irene ; Okoniewski, Michal ; Patrignani, Andrea ; Ludin, Katja ; Xu, Zhenyu ; Steinmann, Beat ; Carrel, Thierry ; Röthlisberger, Benno ; Schlapbach, Ralph ; Bruggmann, Rémy ; Matyas, Gabor

In: Nucleic Acids Research, 2015, vol. 43, no. 11, p. e76-e76

Identification of a SIRT1 Mutation in a Family with Type 1 Diabetes

Biason-Lauber, Anna ; Böni-Schnetzler, Marianne ; Hubbard, Basil P. ; Bouzakri, Karim ; Brunner, Andrea ; Cavelti-Weder, Claudia ; Keller, Cornelia ; Meyer-Böni, Monika ; Meier, Daniel T. ; Brorsson, Caroline ; Timper, Katharina ; Leibowitz, Gil ; Patrignani, Andrea ; Bruggmann, Remy ; Boily, Gino ; Zulewski, Henryk ; Geier, Andreas ; Cermak, Jennifer M. ; Elliott, Peter ; Ellis, James L. ; Westphal, Christoph ; Knobel, Urs ; Eloranta, Jyrki J. ; Kerr-Conte, Julie ; Pattou, François ; Konrad, Daniel ; Matter, Christian M. ; Fontana, Adriano ; Rogler, Gerhard ; Schlapbach, Ralph ; Regairaz, Camille ; Carballido, José M. ; Glaser, Benjamin ; McBurney, Michael W. ; Pociot, Flemming ; Sinclair, David A. ; Donath, Marc Y.

In: Cell Metabolism, 2013, vol. 17, no. 3, p. 448-455

Type 1 diabetes is caused by autoimmune-mediated β cell destruction leading to insulin deficiency. The histone deacetylase SIRT1 plays an essential role in modulating several age-related diseases. Here we describe a family carrying a mutation in the SIRT1 gene, in which all five affected members developed an autoimmune disorder: four developed type 1 diabetes, and one developed ulcerative...