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Bcl-2 family members: intracellular targeting, membrane-insertion, and changes in subcellular localization

Schinzel, Anna ; Kaufmann, Thomas ; Borner, Christoph

In: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2004, vol. 1644, no. 2, p. 95-105

The members of the Bcl-2 family of proteins are crucial regulators of apoptosis. In order to determine cell fate, these proteins must be targeted to distinct intracellular membranes, including the mitochondrial outer membrane (MOM), the membrane of the endoplasmic reticulum (ER) and its associated nuclear envelope. The targeting sequences and mechanisms that mediate the specificity of these...