In: Journal of Controlled Release, 2017, vol. 264, no. Supplement C, p. 14–23
Liposomes formulated from the 1,3-diamidophospholipid Pad-PC-Pad are shear- responsive and thus promising nano-containers to specifically release a vasodilator at stenotic arteries. The recommended preclinical safety tests for therapeutic liposomes of nanometer size include the in vitro assessment of complement activation and the evaluation of the associated risk of complement...
|
In: Cardiovascular Research, 2013, vol. 99, no. 2, p. 328-333
|
In: Nanomedicine: Nanotechnology, Biology and Medicine, 2016, vol. 12, no. 3, p. 845–849
Cardio-vascular diseases are the main cause of death, emphasizing the need to improve patient treatment and survival. One therapeutic approach is a liposome-based drug carrier system specifically targeting constricted arteries. The recently discovered mechano-sensitive liposomes use hemodynamic shear-stress differences between healthy and constricted blood vessels as trigger for drug release....
|
In: Cardiovascular Research, 2013, vol. 99, no. 2, p. 328-333
Stenosed segments of arteries significantly alter the blood flow known from healthy vessels. In particular, the wall shear stress at critically stenosed arteries is at least an order of magnitude higher than in healthy situations. This alteration represents a change in physical force and might be used as a trigger signal for drug delivery. Mechanosensitive drug delivery systems, that...
|
