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The C. elegans sex determination protein MOG-3 functions in meiosis and binds to the CSL co-repressor CIR-1

Kasturi, Prasad ; Zanetti, Simone ; Passannante, Myriam ; Saudan, Zarifja ; Müller, Fritz ; Puoti, Alessandro

In: Developmental Biology, 2010, vol. 344, no. 2, p. 593-602

In the germ line of the Caenorhabditis elegans hermaphrodite, nuclei either proliferate through mitosis or initiate meiosis, finally differentiating as spermatids or oocytes. The production of oocytes requires repression of the fem-3 mRNA by cytoplasmic FBF and nuclear MOG proteins. Here we report the identification of the sex determining gene mog-3 and show that in addition to its role in gamete...