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The C-terminal domain of TPX2 is made of alpha-helical tandem repeats

Sanchez-Pulido, Luis ; Perez, Laurent ; Kuhn, Steffen ; Vernos, Isabelle ; Andrade-Navarro, Miguel A.

In: BMC structural biology, 2016, vol. 16, p. 17

Background: TPX2 (Targeting Protein for Xklp2) is essential for spindle assembly, activation of the mitotic kinase Aurora A and for triggering microtubule nucleation. Homologs of TPX2 in Chordata and plants were previously identified. Currently, proteins of the TPX2 family have little structural information and only small parts are covered by defined protein domains. Methods: We have used ...