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Comparison of a novel biodegradable polymer sirolimus-eluting stent with a durable polymer everolimus-eluting stent: 5-year outcomes of the randomized bioflow-ii trial

Lefèvre, Thierry ; Haude, Michael ; Neumann, Franz-Josef ; Stang, Karl ; Skurk, Carsten ; Slagboom, Ton ; Sabaté, Manel ; Goicolea, Javier ; Barragan, Paul ; Cook, Stéphane ; Macia, Jean-Christophe ; Windecker, Stephan

In: JACC: Cardiovascular Interventions, 2018, vol. 11, no. 10, p. 995–1002

ObjectivesThe authors aimed to compare long-term data of an ultrathin cobalt- chromium stent with passive silicon carbide coating and an active biodegradable polymer that releases sirolimus (O-SES) (Orsiro, BIOTRONIK, Bülach, Switzerland) with the durable polymer-based Xience Prime everolimus-eluting stent (X-EES) (Abbott Vascular, Santa Clara, California).BackgroundBiodegradable polymer...

Reperfusion therapy for ST elevation acute myocardial infarction 2010/2011: current status in 37 ESC countries

Kristensen, Steen D. ; Laut, Kristina G. ; Fajadet, Jean ; Kaifoszova, Zuzana ; Kala, Petr ; Di Mario, Carlo ; Wijns, William ; Clemmensen, Peter ; Agladze, Vaja ; Antoniades, Loizos ; Alhabib, Khalid F. ; De Boer, Menko-Jan ; Claeys, Marc J. ; Deleanu, Dan ; Dudek, Dariusz ; Erglis, Andrejs ; Gilard, Martine ; Goktekin, Omer ; Guagliumi, Giulio ; Gudnason, Thorarinn ; Hansen, Kim Wadt ; Huber, Kurt ; James, Stefan ; Janota, Tomáš ; Jennings, Siobhan ; Kajander, Olli ; Kanakakis, John ; Karamfiloff, Kiril K. ; Kedev, Sasko ; Kornowski, Ran ; Ludman, Peter F. ; Merkely, Béla ; Milicic, Davor ; Najafov, Ruslan ; Nicolini, Francesca A. ; Noč, Marko ; Ostojic, Miodrag ; Pereira, Hélder ; Radovanovic, Dragana ; Sabaté, Manel ; Sobhy, Mohamed ; Sokolov, Maxim ; Studencan, Martin ; Terzic, Ibrahim ; Wahler, Steffen ; Widimsky, Petr ; Mühlberger, Volker ; Najafov, Ruslan ; Legrand, V. ; Spuzic, M. ; Hajric, R. ; Markota, D. ; Srdic, S. ; Jorgova, Julia ; Velchev, Vassil ; Petrov, Ivo ; Nikolic Heitzler, V. ; Babic, Z. ; Nicolaides, Evagoras ; Christodulides, Theodoros ; Georgiou, Panagiota ; Jansky, Petr ; Stasek, Josef ; Terkelsen, Christian Juhl ; Galatius, Søren ; Sørensen, Rikke ; Sobhy, Mohamed ; Shal, Ahmed El ; Romppanen, Hannu ; Müller, Alfred ; Rustige, Jörg ; Alexopoulos, Dimitrios ; Kallikazaros, Ioannis ; Papaioannou, Georgios ; Becker, David ; Ungi, Imre ; Kiss, Robert Gabor ; Skuladottir, Frida Bjork ; Bjornsdottir, Thora K. ; Cavanagh, Brendan ; Twomey, Kathleen ; Daly, Kieran ; Matetzky, Shlomi ; De Luca, Leonardo ; Cremonesi, Alberto ; Bovenzi, Francesco ; Zakke, IIja ; Maca, Aija ; Narbute, Inga ; Antov, S. ; Koch, Karel T. ; Mimoso, Jorge ; Almeida, Manuel ; Pereira, Ernesto ; Tatu, Gabriel ; Vinereanu, Dragos ; D'Angeli, Cinzia ; Nedeljkovic, Milan ; Vukcevic, Vladan ; Dobric, Milan ; Hricak, V. ; Kovař, F. ; Kurray, P. ; Peral, Vincente ; Tresserras, Ricard ; Regueiro, Ander ; Erne, Paul ; Rickli, Hans ; Windecker, Stephan ; Kozan, Omer ; Ertas, Gokhan ; Kervan, Umit ; Birkhead, John ; Sokolov, Yuriy

In: European Heart Journal, 2014, vol. 35, no. 29, p. 1957-1970

Comparison of a novel biodegradable polymer sirolimus-eluting stent With a durable polymer everolimus-eluting stent results of the randomized BIOFLOW-II trial

Windecker, Stephan ; Haude, Michael ; Neumann, Franz-Josef ; Stangl, karl ; Witzenbichler, Bernhard ; Slagboom, Ton ; Sabaté, Manel ; Goicolea, Javier ; Barragan, Paul ; Cook, Stéphane ; Piot, Christophe ; Richardt, Gert ; Merkely, Béla ; Schneider, Henrik ; Bilger, Johannes ; Erne, Paul ; Waksman, Ron ; Zaugg, Serge ; Jüni, Peter ; Lefèvre, Thierry

In: Circulation: Cardiovascular Interventions, 2015, vol. 8, no. 2, p. e001441

Background—Biodegradable polymers for release of antiproliferative drugs from drug-eluting stents aim to improve vascular healing. We assessed noninferiority of a novel ultrathin strut drug-eluting stent releasing sirolimus from a biodegradable polymer (Orsiro, O-SES) compared with the durable polymer Xience Prime everolimus-eluting stent (X-EES) in terms of the primary end...