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Hemozoin-catalyzed precipitation polymerization as an assay for malaria diagnosis

Rifaie-Graham, Omar ; Pollard, Jonas ; Raccio, Samuel ; Balog, Sandor ; Rusch, Sebastian ; Hernández-Castañeda, María Andrea ; Mantel, Pierre-Yves ; Beck, Hans-Peter ; Bruns, Nico

In: Nature Communications, 2019, vol. 10, no. 1, p. 1369

Methods to diagnose malaria are of paramount interest to eradicate the disease. Current methods have severe limitations, as they are either costly or not sensitive enough to detect low levels of parasitemia. Here we report an ultrasensitive, yet low- resource chemical assay for the detection and quantification of hemozoin, a biomarker of all Plasmodium species. Solubilized hemozoin catalyzes...