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VGLUT1 binding to endophilin or intersectin1 and dynamin phosphorylation in a diurnal context

Richter, Karin ; Schmutz, Isabelle ; Darna, Mahesh ; Zander, Johannes-F ; Chavan, Rohit ; Albrecht, Urs ; Ahnert-Hilger, Gudrun

In: Neuroscience, 2018, vol. 371, p. 29–37

Glutamate is concentrated into synaptic vesicles (SV) by the vesicular glutamate transporters (VGLUT) 1 and 2. VGLUTs also harbor a Na+/Pi-transport activity when residing at the plasma membrane. Here we aimed to identify whether the diurnal switches of VGLUT1 parallels interactions with or modification of endocytic proteins.VGLUT1 and dynamin bind to SH3 domains of either endophilin (Enph)...

Dysregulation of Rho GTPases in the αPix/Arhgef6 mouse model of X-linked intellectual disability is paralleled by impaired structural and synaptic plasticity and cognitive deficits

Ramakers, Ger J.A. ; Wolfer, David ; Rosenberger, Georg ; Kuchenbecker, Kerstin ; Kreienkamp, Hans-Jürgen ; Prange-Kiel, Janine ; Rune, Gabriele ; Richter, Karin ; Langnaese, Kristina ; Masneuf, Sophie ; Bösl, Michael R. ; Fischer, Klaus-Dieter ; Krugers, Harm J. ; Lipp, Hans-Peter ; van Galen, Elly ; Kutsche, Kerstin

In: Human Molecular Genetics, 2012, vol. 21, no. 2, p. 268-286

Time of day-dependent sorting of the vesicular glutamate transporter to the plasma membrane

Darna, Mahesh ; Schmutz, Isabelle ; Richter, Karin ; Yelamanchili, Sowmya V. ; Pendyala, Gurudutt ; Höltje, Markus ; Albrecht, Urs ; Ahnert-Hilger, Gudrun

In: Journal of Biological Chemistry, 2009, vol. 284, no. 7, p. 4300-4307

Neurotransmitters are concentrated into synaptic vesicles by VGLUT (vesicular glutamate transporter) or VGAT (vesicular GABA transporter). The number of VGLUTs per vesicle determines the amount of stored neurotransmitter, thereby influencing postsynaptic response. Recently, we described a strong diurnal cycling of the amount of VGLUT1 on synaptic vesicles prepared from whole mouse brain at...