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Bax function in the absence of mitochondria in the primitive protozoan Giardia lamblia

Hehl, Adrian B. ; Regos, Attila ; Schraner, Elisabeth ; Schneider, André

In: PLoS ONE, 2007, vol. 2, no. 5, p. e488

Bax-induced permeabilization of the mitochondrial outer membrane and release of cytochrome c are key events in apoptosis. Although Bax can compromise mitochondria in primitive unicellular organisms that lack a classical apoptotic machinery, it is still unclear if Bax alone is sufficient for this, or whether additional mitochondrial components are required. The protozoan parasite Giardia lamblia...