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Cell cycle constraints and environmental control of local DNA hypomethylation in α-proteobacteria

Ardissone, Silvia ; Redder, Peter ; Russo, Giancarlo ; Frandi, Antonio ; Fumeaux, Coralie ; Patrignani, Andrea ; Schlapbach, Ralph ; Falquet, Laurent ; Viollier, Patrick H.

In: PLOS Genetics, 2016, vol. 12, no. 12, p. e1006499

Heritable DNA methylation imprints are ubiquitous and underlie genetic variability from bacteria to humans. In microbial genomes, DNA methylation has been implicated in gene transcription, DNA replication and repair, nucleoid segregation, transposition and virulence of pathogenic strains. Despite the importance of local (hypo)methylation at specific loci, how and when these patterns are...