Università della Svizzera italiana

ACKR3 expression on diffuse large B cell lymphoma is required for tumor spreading and tissue infiltration

Puddinu, Viola ; Casella, Sabrina ; Radice, Egle ; Thelen, Sylvia ; Dirnhofer, Stefan ; Bertoni, Francesco ; Thelen, Marcus

In: Oncotarget, 2017, vol. 8, no. 49, p. 85068-85084

Diffuse large B cell lymphoma (DLBCL) is the most frequent lymphoma accounting for more than the 30% of the cases. Involvement of extranodal sites, such as bone marrow and central nervous system, is associated with poor prognosis. A contribution of the chemokine system in these processes is assumed as it is known as a critical regulator of the metastatic process in cancer. The atypical...

Université de Fribourg

NAB2 is a novel immune stimulator of MDA-5 that promotes a strong type I interferon response

Oberson, Anne ; Spagnuolo, Lorenzo ; Puddinu, Viola ; Barchet, Winfried ; Rittner, Karola ; Bourquin, Carole

In: Oncotarget, 2018, vol. 9, no. 5, p. -

Novel adjuvants are needed to increase the efficacy of vaccine formulations and immune therapies for cancer and chronic infections. In particular, adjuvants that promote a strong type I IFN response are required, since this cytokine is crucial for the development of efficient anti-tumoral and anti-viral immunity. Nucleic acid band 2 (NAB2) is a double- stranded RNA molecule isolated from...