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REV-ERBα regulates Fgf21 expression in the liver via hepatic nuclear factor 6

Chavan, Rohit ; Preitner, Nadia ; Okabe, Takashi ; Mansencal Strittmatter, Laureen ; Xu, Cheng ; Ripperger, Jürgen A. ; Pitteloud, Nelly ; Albrecht, Urs

In: Biology Open, 2017, vol. 6, no. 1, p. 1–7

The circadian clock contributes to the timing of many body functions including metabolism and reproduction. The hepatokine fibroblast growth factor 21 (FGF21) is a critical metabolic regulator involved in modulation of fertility. Here we show that lack of the clock component REV-ERBα elevates FGF21 levels in liver and plasma. At the molecular level, REV-ERBα modulates the expression of...