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Mak5 and Ebp2 act together on early Pre-60S particles and their reduced functionality bypasses the requirement for the essential Pre-60S factor Nsa1

Pratte, Dagmar ; Singh, Ujjwala ; Murat, Guillaume ; Kressler, Dieter

In: PLoS ONE, 2013, vol. 8, no. 12, p. e82741

Ribosomes are the molecular machines that translate mRNAs into proteins. The synthesis of ribosomes is therefore a fundamental cellular process and consists in the ordered assembly of 79 ribosomal proteins (r-proteins) and four ribosomal RNAs (rRNAs) into a small 40S and a large 60S ribosomal subunit that form the translating 80S ribosomes. Most of our knowledge concerning this dynamic multi-step...

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Synchronizing nuclear import of ribosomal proteins with ribosome assembly

Kressler, Dieter ; Bange, Gert ; Ogawa, Yutaka ; Stjepanovic, Goran ; Bradatsch, Bettina ; Pratte, Dagmar ; Amlacher, Stefan ; Strauß, Daniela ; Yoneda, Yoshihiro ; Katahira, Jun ; Sinning, Irmgard ; Hurt, Ed

In: Science, 2012, vol. 338, no. 6107, p. 666-671

Ribosomal proteins are synthesized in the cytoplasm, before nuclear import and assembly with ribosomal RNA (rRNA). Little is known about coordination of nucleocytoplasmic transport with ribosome assembly. Here, we identify a transport adaptor, symportin 1 (Syo1), that facilitates synchronized coimport of the two 5S-rRNA binding proteins Rpl5 and Rpl11. In vitro studies revealed that Syo1...

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