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pH-responsive nano-self-assemblies of the anticancer drug 2-hydroxyoleic acid

Prajapati, Rama ; Gontsarik, Mark ; Yaghmur, Anan ; Salentinig, Stefan

In: Langmuir, 2019, vol. 35, no. 24, p. 7954–7961

pH-responsive lipid nanocarriers have the potential to selectively target the acidic extracellular pH environment of cancer tissues and may further improve the efficacy of chemotherapeutics by minimizing their toxic side-effects. Here, we present the design and characterization of pH-sensitive nano-self-assemblies of the poorly water-soluble anticancer drug 2-hydroxyoleic acid (2OHOA) with...