Université de Fribourg

Bevacizumab specifically decreases elevated levels of circulating KIT+CD11b+ cells and IL-10 in metastatic breast cancer patients

Cattin, Sarah ; Fellay, Benoît ; Pradervand, Sylvain ; Trojan, Andreas ; Ruhstaller, Thomas ; Rüegg, Curzio ; Fürstenberger, Gregor

In: Oncotarget, 2016, vol. 7, no. 10, p. 11137–11150

Whether bevacizumab exerts its anti-tumor properties through systemic effects beyond local inhibition of angiogenesis and how these effects can be monitored in patients, remain largely elusive. To address these questions, we investigated bone marrow-derived cells and cytokines in the peripheral blood of metastatic breast cancer patients undergoing therapy with...

Université de Fribourg

Wounding of Arabidopsis halleri leaves enhances cadmium accumulation that acts as a defense against herbivory

Plaza, Sonia ; Weber, Johann ; Pajonk, Simone ; Thomas, Jérôme ; Talke, Ina N. ; Schellenberg, Maja ; Pradervand, Sylvain ; Burla, Bo ; Geisler, Markus ; Martinoia, Enrico ; Krämer, Ute

In: BioMetals, 2015, vol. 28, no. 3, p. 521–528

Approximately 0.2 % of all angiosperms are classified as metal hyperaccumulators based on their extraordinarily high leaf metal contents, for example >1 % zinc, >0.1 % nickel or >0.01 % cadmium (Cd) in dry biomass. So far, metal hyperaccumulation has been considered to be a taxon-wide, constitutively expressed trait, the extent of which depends solely on available metal concentrations in the...