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Eliminating the VGlut2-dependent glutamatergic transmission of parvalbumin-expressing neurons leads to deficits in locomotion and vocalization, decreased pain sensitivity, and increased dominance

Roccaro-Waldmeyer, Diana M. ; Girard, Franck ; Milani, Daniele ; Vannoni, Elisabetta ; Prétôt, Laurent ; Wolfer, David P. ; Celio, Marco R.

In: Frontiers in Behavioral Neuroscience, 2018, vol. 12, p. -

The calcium-binding protein parvalbumin (PV) is a recognized marker of short-axon GABA-ergic neurons in the cortex and the hippocampus. However in addition, PV is expressed by excitatory, glutamatergic neurons in various areas of the brain and spinal cord. Depending on the location of these neurons, loading of their synaptic vesicles with glutamate is mediated by either of three vesicular...