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T cells loaded with magnetic nanoparticles are retained in peripheral lymph nodes by the application of a magnetic field

Sanz‑Ortega, Laura ; Rojas, José M. ; Marcos, Ana ; Portilla, Yadileiny ; Stein, Jens V. ; Barber, Domingo F.

In: Journal of Nanobiotechnology, 2019, vol. 17, no. 1, p. 14

T lymphocytes are highly dynamic elements of the immune system with a tightly regulated migration. T cell-based transfer therapies are promising therapeutic approaches which in vivo efficacy is often limited by the small proportion of administered cells that reaches the region of interest. Manipulating T cell localisation to improve specific targeting will increase the effectiveness of these...