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Tubular deficiency of von Hippel-Lindau attenuates renal disease progression in anti-GBM glomerulonephritis

Theilig, Franziska ; Enke, Anne Kathrin ; Scolari, Brigitte ; Polzin, Danny ; Bachmann, Sebastian ; Koesters, Robert

In: The American Journal of Pathology, 2011, vol. 179, no. 5, p. 2177–2188

In many kidney diseases, the original insult primarily involves the glomerulus and may then pass onto the tubulointerstitium. Several hypotheses link glomerular disease to tubular injury; perhaps the foremost hypothesis involves chronic tubular hypoxia. The reported effects of hypoxia and consecutive stabilization of hypoxia-inducible factors (HIFs), however, are controversial. Hypoxia induces...