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Impairment of acquisition of intravenous cocaine self-administration by RNA-interference of dopamine D1-receptors in the nucleus accumbens shell

Pisanu, Augusta ; Lecca, Daniele ; Valentini, Valentina ; Bahi, Amine ; Dreyer, Jean-Luc ; Cacciapaglia, Fabio ; Scifo, Andrea ; Piras, Giovanna ; Cadoni, Cristina ; Chiara, Gaetano Di

In: Neuropharmacology, 2015, vol. 89, p. 398–411

Microdialysis during i.v. drug self-administration (SA) have implicated nucleus accumbens (NAc) shell DA in cocaine and heroin reinforcement. However, this correlative evidence has not been yet substantiated by experimental evidence obtained by studying the effect of selective manipulation of NAc shell DA transmission on cocaine and heroin SA. In order to investigate this issue, DA D1a receptor...