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FTY720 and two novel butterfly derivatives exert a general anti-inflammatory potential by reducing immune cell adhesion to endothelial cells through activation of S1P3 and phosphoinositide 3-kinase

Imeri, Faik ; Blanchard, Olivier ; Jenni, Aurelio ; Schwalm, Stephanie ; Wünsche, Christin ; Zivkovic, Aleksandra ; Stark, Holger ; Pfeilschifter, Josef ; Huwiler, Andrea

In: Naunyn-Schmiedeberg's Archives of Pharmacology, 2015, vol. 388, no. 12, p. 1283-1292

Downregulation of sphingosine 1-phosphate (S1P) receptor 1 by dexamethasone inhibits S1P-induced mesangial cell migration

Koch, Alexander ; Jäger, Manuel ; Völzke, Anja ; Grammatikos, Georgios ; zu Heringdorf, Dagmar Meyer ; Huwiler, Andrea ; Pfeilschifter, Josef

In: Biological Chemistry, 2015, vol. 396, no. 6-7, p. 803-812

Sphingosine kinase 2 deficiency increases proliferation and migration of renal mouse mesangial cells and fibroblasts

Schwalm, Stephanie ; Timcheva, Tankica Maneva ; Filipenko, Iuliia ; Ebadi, Mahsa ; Hofmann, Lotte P. ; Zangemeister-Wittke, Uwe ; Pfeilschifter, Josef ; Huwiler, Andrea

In: Biological Chemistry, 2015, vol. 396, no. 6-7, p. 813-825

Cystathionine γ Lyase Sulfhydrates the RNA Binding Protein Human Antigen R to Preserve Endothelial Cell Function and Delay Atherogenesis

Bibli, Sofia-Iris ; Hu, Jiong ; Sigala, Fragiska ; Wittig, Ilka ; Heidler, Juliana ; Zukunft, Sven ; Tsilimigras, Diamantis I. ; Randriamboavonjy, Voahanginirina ; Wittig, Janina ; Kojonazarov, Baktybek ; Schürmann, Christoph ; Siragusa, Mauro ; Siuda, Daniel ; Luck, Bert ; Malik, Randa Abdel ; Filis, Konstantinos A. ; Zografos, George ; Chen, Chen ; Wang, Dao Wen ; Pfeilschifter, Josef ; Brandes, Ralf P. ; Szabo, Csaba ; Papapetropoulos, Andreas ; Fleming, Ingrid

In: Circulation, 2019, vol. 139, no. 1, p. 101–114

Hydrogen sulfide (H2S), generated by cystathionine γ lyase (CSE), is an important endogenous regulator of vascular function. The aim of the present study was to investigate the control and consequences of CSE activity in endothelial cells under physiological and proatherogenic conditions.

L1-CAM expression in ccRCC correlates with shorter patients survival times and confers chemoresistance in renal cell carcinoma cells

Doberstein, Kai ; Wieland, Anja ; Lee, Sophia B. Boyoung ; Blaheta, Roman A. Alexander ; Wedel, Steffen ; Moch, Holger ; Schraml, Peter ; Pfeilschifter, Josef ; Kristiansen, Glen ; Gutwein, Paul

In: Carcinogenesis, 2011, vol. 32, no. 3, p. 262-270

Sphingosine kinase 1 and 2 regulate the capacity of mesangial cells to resist apoptotic stimuli in an opposing manner

Hofmann, Lotte P. ; Ren, Shuyu ; Schwalm, Stephanie ; Pfeilschifter, Josef ; Huwiler, Andrea

In: Biological Chemistry, 2008, vol. 389, no. 11, p. 1399-1407

CD14 Works with Toll-Like Receptor 2 to Contribute to Recognition and Control of Listeria monocytogenes Infection

Janot, Laure ; Secher, Thomas ; Torres, David ; Maillet, Isabelle ; Pfeilschifter, Josef ; Quesniaux, Valerie F. J. ; Landmann, Regine ; Ryffel, Bernhard ; Erard, François

In: The Journal of Infectious Diseases, 2008, vol. 198, no. 1, p. 115-124

Co-ordinate Expression of GTP Cyclohydrolase I and Inducible Nitric Oxide Synthase in Rat Mesangial Cells

Plüss, Christoph ; Kunz, Dieter ; Redweik, Udo ; Blau, Nenad ; Pfeilschifter, Josef

In: Pteridines, 1995, vol. 6, no. 3, p. 129-131

Hypoxia and lipid signaling

Huwiler, Andrea ; Pfeilschifter, Josef

In: Biological Chemistry, 2006/387/10/11/1321-1328