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Effects of lactate on the early visual cortex of non-human primates, investigated by pharmaco-MRI and neurochemical analysis

Pföstl, Veronika von ; Li, Juan ; Zaldivar, Daniel ; Goense, Jozien ; Zhang, Xiaozhe ; Serr, Nadine ; Logothetis, Nikos K. ; Rauch, Alexander

In: NeuroImage, 2012, vol. 61, no. 1, p. 98–105

In contrast to the limited use of functional magnetic resonance imaging (fMRI) in clinical diagnostics, it is currently a mainstay of neuroimaging in clinical and basic brain research. However, its non-invasive use in combination with its high temporal and spatial resolution would make fMRI a perfect diagnostic tool. We are interested in whether a pharmacological challenge imposed on the brain...

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Measuring multiple neurochemicals and related metabolites in blood and brain of the rhesus monkey by using dual microdialysis sampling and capillary hydrophilic interaction chromatography–mass spectrometry

Li, Juan ; Pföstl, Veronika von ; Zaldivar, Daniel ; Zhang, Xiaozhe ; Logothetis, Nikos ; Rauch, Alexander

In: Analytical and Bioanalytical Chemistry, 2012, p. -

In vivo measurement of multiple functionally related neurochemicals and metabolites (NMs) is highly interesting but remains challenging in the field of basic neuroscience and clinical research. We present here an analytical method for determining five functionally and metabolically related polar substances, including acetylcholine (quaternary ammonium), lactate and pyruvate (organic acids), as...

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