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Biological response of an in vitro human 3D lung cell model exposed to brake wear debris varies based on brake pad formulation

Barosova, Hana ; Chortarea, Savvina ; Peikertova, Pavlina ; J. D. Clift, Martin ; Petri-Fink, Alke ; Kukutschova, Jana ; Rothen-Rutishauser, Barbara

In: Archives of Toxicology, 2018, vol. 92, no. 7, p. 2339–2351

Wear particles from automotive friction brake pads of various sizes, morphology, and chemical composition are significant contributors towards particulate matter. Knowledge concerning the potential adverse effects following inhalation exposure to brake wear debris is limited. Our aim was, therefore, to generate brake wear particles released from commercial low-metallic and non-asbestos organic...