In: PLOS Genetics, 2016, vol. 12, no. 12, p. e1006499
Heritable DNA methylation imprints are ubiquitous and underlie genetic variability from bacteria to humans. In microbial genomes, DNA methylation has been implicated in gene transcription, DNA replication and repair, nucleoid segregation, transposition and virulence of pathogenic strains. Despite the importance of local (hypo)methylation at specific loci, how and when these patterns are...
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In: Human Genetics, 2007, vol. 122, no. 1, p. 23-32
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In: Nucleic Acids Research, 2015, vol. 43, no. 11, p. e76-e76
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In: Nucleic Acids Research, 2014, vol. 42, no. 14, p. e115-e115
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In: BMC Genomics, 2014, vol. 15, no. 1, p. 16
Background: High-throughput sequencing has opened up exciting possibilities in population and conservation genetics by enabling the assessment of genetic variation at genome-wide scales. One approach to reduce genome complexity, i.e. investigating only parts of the genome, is reduced-representation library (RRL) sequencing. Like similar approaches, RRL sequencing reduces ascertainment bias due to...
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In: Cell Metabolism, 2013, vol. 17, no. 3, p. 448-455
Type 1 diabetes is caused by autoimmune-mediated β cell destruction leading to insulin deficiency. The histone deacetylase SIRT1 plays an essential role in modulating several age-related diseases. Here we describe a family carrying a mutation in the SIRT1 gene, in which all five affected members developed an autoimmune disorder: four developed type 1 diabetes, and one developed ulcerative...
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