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Secretome of adipose-derived mesenchymal stem cells promotes skeletal muscle regeneration through synergistic action of extracellular vesicle cargo and soluble proteins

Mitchell, Robert ; Mellows, Ben ; Sheard, Jonathan ; Antonioli, Manuela ; Kretz, Oliver ; Chambers, David ; Zeuner, Marie-Theres ; Tomkins, James E. ; Denecke, Bernd ; Musante, Luca ; Joch, Barbara ; Debacq-Chainiaux, Florence ; Holthofer, Harry ; Ray, Steve ; Huber, Tobias B. ; Dengjel, Jörn ; De Coppi, Paolo ; Widera, Darius ; Patel, Ketan

In: Stem Cell Research & Therapy, 2019, vol. 10, no. 1, p. 116

The mechanisms underpinning the regenerative capabilities of mesenchymal stem cells (MSC) were originally thought to reside in their ability to recognise damaged tissue and to differentiate into specific cell types that would replace defective cells. However, recent work has shown that molecules produced by MSCs (secretome), particularly those packaged in extracellular vesicles (EVs), rather...

Oral Abstracts 7: RA ClinicalO37. Long-Term Outcomes of Early RA Patients Initiated with Adalimumab Plus Methotrexate Compared with Methotrexate Alone Following a Targeted Treatment Approach

Fleischmann, Roy ; van Vollenhoven, Ronald F. ; Smolen, Josef ; Emery, Paul ; Florentinus, Stefan ; Rathmann, Suchitrita ; Kupper, Hartmut ; Kavanaugh, Arthur ; Taylor, Peter ; Genovese, Mark ; Keystone, Edward C. ; Drescher, Edit ; Berclaz, Pierre-Yves ; Lee, Chin ; Fidelus-Gort, Rosalind ; Schlichting, Douglas ; Beattie, Scott ; Luchi, Monica ; Macias, William ; Kavanaugh, Arthur ; Emery, Paul ; van Vollenhoven, Ronald F. ; Dikranian, Ara H. ; Alten, Rieke ; Klearman, Micki ; Musselman, David ; Agarwal, Sunil ; Green, Jennifer ; Gabay, Cem ; Weinblatt, Michael E. ; Schiff, Michael H. ; Fleischmann, Roy ; Valente, Robert ; van der Heijde, Desiree ; Citera, Gustavo ; Zhao, Cathy ; Maldonado, Michael A. ; Rakieh, Chadi ; Nam, Jacqueline L. ; Hunt, Laura ; Villeneuve, Edith ; Bissell, Lesley-Anne ; Das, Sudipto ; Conaghan, Philip ; McGonagle, Dennis ; Wakefield, Richard J. ; Emery, Paul ; Wright, Helen L. ; Thomas, Huw B. ; Moots, Robert ; Edwards, Steven W. ; Hamann, Philip ; Heward, James ; McHugh, Neil ; Lindsay, Mark A. ; Haroon, Muhammad ; Giles, Jon T. ; Winchester, Robert ; FitzGerald, Oliver ; Karaderi, Tugce ; Cohen, Carla J. ; Keidel, Sarah ; Appleton, Louise H. ; Macfarlane, Gary J. ; Siebert, Stefan ; Evans, David ; Paul Wordsworth, B. ; Plant, Darren ; Bowes, John ; Orozco, Gisela ; Morgan, Ann W. ; Wilson, Anthony G. ; Isaacs, John ; Barton, Anne ; Williams, Frances M. ; Livshits, Gregory ; Spector, Tim ; MacGregor, Alexander ; Williams, Frances M. ; Scollen, Serena ; Cao, Dandan ; Memari, Yasin ; Hyde, Craig L. ; Zhang, Baohong ; Sidders, Benjamin ; Ziemek, Daniel ; Shi, Yujian ; Harris, Juliette ; Harrow, Ian ; Dougherty, Brian ; Malarstig, Anders ; McEwen, Robert ; Stephens, Joel L. ; Patel, Ketan ; Shin, So-Youn ; Surdulescu, Gabriela ; He, Wen ; Jin, Xin ; McMahon, Stephen B. ; Soranzo, Nicole ; John, Sally ; Wang, Jun ; Spector, Tim D. ; Baker, Jonathan ; Litherland, Gary J. ; Rowan, Andrew D. ; Kite, Kerry A. ; Bayley, Rachel ; Yang, Peiming ; Smith, Jacqueline P. ; Williams, Julie ; Harper, Lorraine ; Kitas, George D. ; Buckley, Christopher ; Young, Stephen P. ; Fitzpatrick, Martin A. ; Young, Stephen P. ; McGettrick, Helen M. ; Filer, Andrew ; Raza, Karim ; Nash, Gerard ; Buckley, Christopher ; Muthana, Munitta ; Davies, Holly ; Khetan, Sachin ; Adeleke, Gbadebo ; Hawtree, Sarah ; Tazzyman, Simon ; Morrow, Fiona ; Ciani, Barbara ; Wilson, Gerry ; Quirke, Anne-Marie ; Lugli, Elena ; Wegner, Natalia ; Charles, Peter ; Hamilton, Bart ; Chowdhury, Muslima ; Ytterberg, Jimmy ; Potempa, Jan ; Fisher, Benjamin ; Thiele, Geoffrey ; Mikuls, Ted ; Venables, Patrick ; Adebajo, Adewale O. ; Kavanaugh, Arthur ; Mease, Philip ; Gomez-Reino, Juan J. ; Wollenhaupt, Jurgen ; Hu, ChiaChi ; Stevens, Randall ; Sieper, Joachim ; van der Heijde, Desiree ; Dougados, Maxime ; Van den Bosch, Filip ; Goupille, Philippe ; Rathmann, Suchitrita S. ; Pangan, Aileen L. ; van der Heijde, Desiree ; Sieper, Joachim ; Maksymowych, Walter P. ; Brown, Matthew A. ; Rathmann, Suchitrita ; Pangan, Aileen L. ; Sieper, Joachim ; van der Heijde, Desiree ; Elewaut, Dirk ; Pangan, Aileen L. ; Anderson, Jaclyn ; Haroon, Muhammad ; Ramasamy, Pathma ; O'Rourke, Michael ; Murphy, Conor ; Fitzgerald, Oliver ; Jani, Meghna ; Moore, Sarah ; Mirjafari, Hoda ; Macphie, Elizabeth ; Chinoy, Hector ; Rao, Chan ; McLoughlin, Yokemei ; Preeti, Shah

In: Rheumatology, 2013, vol. 52, p. i44-i55